Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.5
USERS' SCORE
Moderately Good
Based on 47 Reviews
7.8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Wild Caught Fish Oil Concentrate
1250 mg
†
Total Omega-3 Fatty Acids as TG
1055 mg
†
EPA (Eicosapentaenoic Acid)
690 mg
†
DHA (Docosahexaenoic Acid)
310 mg
†
Other Omega-3 Fatty Acids
55 mg
†
Top Medical Research Studies
9
Eicosapentaenoic acid influences clotting
We explored how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, influences blood clotting processes. The interest in EPA grew substantially after the 1970s when researchers Dyerberg and Bang noted that Greenland Eskimos had lower rates of coronary disease linked to their diet rich in marine lipids.
Their findings suggested that the higher levels of EPA led to reduced platelet aggregation, which essentially means that the blood clots less easily. This anti-clotting effect is significant since blood clots can lead to serious health issues like heart attacks and strokes.
Although studies have shown these promising effects, it’s crucial to note that much of the initial acclaim came from dietary observations rather than controlled clinical trials. This means that while we can relate high EPA intake to lower health risks in specific populations, we still need more rigorous studies to fully understand the impact of EPA on blood clotting across diverse groups.
Their findings suggested that the higher levels of EPA led to reduced platelet aggregation, which essentially means that the blood clots less easily. This anti-clotting effect is significant since blood clots can lead to serious health issues like heart attacks and strokes.
Although studies have shown these promising effects, it’s crucial to note that much of the initial acclaim came from dietary observations rather than controlled clinical trials. This means that while we can relate high EPA intake to lower health risks in specific populations, we still need more rigorous studies to fully understand the impact of EPA on blood clotting across diverse groups.
Read More
9
We explored the effects of eicosapentaenoic acid (EPA), particularly in the context of acute coronary syndrome (ACS), on blood clotting. The study highlighted how different subclasses of high-density lipoprotein (HDL), particularly HDL2 from ACS patients, interact with platelets during clot formation.
It became clear that HDL2 from ACS patients exhibited a stronger ability to inhibit platelet aggregation compared to HDL from healthy individuals. This ability to reduce clot formation is linked to the presence of specific oxidized polyunsaturated fatty acids in the HDL2 particles.
We observed an inverse relationship between several oxidized fatty acids, such as 18-hydroxyeicosapentaenoic acid (18-HEPE) and others, and platelet aggregation. This means that higher levels of these oxidized fats were associated with less platelet activation and clotting, pointing to their potential role in enhancing the antithrombotic properties of HDL2 in ACS patients.
Overall, the findings suggest that EPA and its oxidized metabolites could play a key role in modifying HDL properties, thereby offering some protection against blood clots in individuals with ACS.
It became clear that HDL2 from ACS patients exhibited a stronger ability to inhibit platelet aggregation compared to HDL from healthy individuals. This ability to reduce clot formation is linked to the presence of specific oxidized polyunsaturated fatty acids in the HDL2 particles.
We observed an inverse relationship between several oxidized fatty acids, such as 18-hydroxyeicosapentaenoic acid (18-HEPE) and others, and platelet aggregation. This means that higher levels of these oxidized fats were associated with less platelet activation and clotting, pointing to their potential role in enhancing the antithrombotic properties of HDL2 in ACS patients.
Overall, the findings suggest that EPA and its oxidized metabolites could play a key role in modifying HDL properties, thereby offering some protection against blood clots in individuals with ACS.
Read More
8
We explored how omega-3 fatty acids, particularly eicosapentaenoic acid (EPA), influence blood clot markers in patients with atrial fibrillation (AF). Our research involved a large group of 2,373 patients, assessing the levels of D-dimer and beta-thromboglobulin (BTG), which are indicators of blood clotting activity and platelet activation.
The results showed that higher total omega-3 fatty acid levels were linked to lower D-dimer and BTG levels, which suggests a potential antithrombotic effect. Notably, the individual omega-3s, including EPA, docosahexaenoic acid (DHA), and others, generally displayed similar associations.
While EPA had a small positive relationship with BTG, DHA, DPA, and ALA were associated with lower BTG levels, indicating varied effects among these fatty acids. Overall, we found that increased omega-3 fatty acid levels could contribute to reduced activation of blood clotting mechanisms in patients with AF, highlighting the potential benefits of omega-3 intake for cardiovascular health.
The results showed that higher total omega-3 fatty acid levels were linked to lower D-dimer and BTG levels, which suggests a potential antithrombotic effect. Notably, the individual omega-3s, including EPA, docosahexaenoic acid (DHA), and others, generally displayed similar associations.
While EPA had a small positive relationship with BTG, DHA, DPA, and ALA were associated with lower BTG levels, indicating varied effects among these fatty acids. Overall, we found that increased omega-3 fatty acid levels could contribute to reduced activation of blood clotting mechanisms in patients with AF, highlighting the potential benefits of omega-3 intake for cardiovascular health.
Read More
Most Useful Reviews
9
Skin condition improved
25 people found this helpful
The ideal dosage for everyday vitamins comes in a plastic jar with protective mica on the lid. The sleek black design conveys quality. The capsules are large, dense, and rich golden colour, with no smell, which delighted me! They swallow easily with a glass of water, and I don’t feel them in my throat. No fishy burps or unpleasant aftertastes! I track my skin condition, especially dryness on my elbows and legs. Without omega, my skin stays dry, needing constant moisturising. With omega, my skin feels normal, soft, and delicate. I can't identify its effects on heart health or blood vessels, but I do maintain good blood pressure for my age.
Read More
9
Less eye fatigue
5 people found this helpful
These vitamins in a plastic jar with a mica lid caught my attention. I was struck by the sleek design, giving it a quality appearance. The large golden capsules are easy to swallow with water, and I've not experienced any unpleasant aftertaste or fishy burps after taking them. Since starting omega, the dry skin on my elbows and legs is no longer an issue; my skin feels soft and smooth. While I can't specifically judge its impact on my heart or joints, my blood pressure remains stable, which is normal for me. Additionally, I've noticed my eyes feel less tired during the day.
Read More
9
Improved skin quality
1 people found this helpful
The ideal dosage for daily vitamins comes in a plastic jar with protective mica on the lid, which I removed initially. The strict black design makes the dietary supplement look presentable and gives an impression of quality. The capsules are large, dense, and a rich golden colour, with no smell, which made me very happy! It swallows well with a glass of water without feeling stuck in my throat, and there's no fishy burp or aftertaste. My skin, which was dry and required moisturising creams without omega, has become soft and delicate with its reception. I haven’t noted its effect on the heart, blood vessels, or joints, except for maintaining good blood pressure appropriate for my age. My vision has improved, as my eyes feel less tired.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.5
- All Researches
9
Eicosapentaenoic acid influences clotting
We explored how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, influences blood clotting processes. The interest in EPA grew substantially after the 1970s when researchers Dyerberg and Bang noted that Greenland Eskimos had lower rates of coronary disease linked to their diet rich in marine lipids.
Their findings suggested that the higher levels of EPA led to reduced platelet aggregation, which essentially means that the blood clots less easily. This anti-clotting effect is significant since blood clots can lead to serious health issues like heart attacks and strokes.
Although studies have shown these promising effects, it’s crucial to note that much of the initial acclaim came from dietary observations rather than controlled clinical trials. This means that while we can relate high EPA intake to lower health risks in specific populations, we still need more rigorous studies to fully understand the impact of EPA on blood clotting across diverse groups.
Their findings suggested that the higher levels of EPA led to reduced platelet aggregation, which essentially means that the blood clots less easily. This anti-clotting effect is significant since blood clots can lead to serious health issues like heart attacks and strokes.
Although studies have shown these promising effects, it’s crucial to note that much of the initial acclaim came from dietary observations rather than controlled clinical trials. This means that while we can relate high EPA intake to lower health risks in specific populations, we still need more rigorous studies to fully understand the impact of EPA on blood clotting across diverse groups.
Read More
9
We explored the effects of eicosapentaenoic acid (EPA), particularly in the context of acute coronary syndrome (ACS), on blood clotting. The study highlighted how different subclasses of high-density lipoprotein (HDL), particularly HDL2 from ACS patients, interact with platelets during clot formation.
It became clear that HDL2 from ACS patients exhibited a stronger ability to inhibit platelet aggregation compared to HDL from healthy individuals. This ability to reduce clot formation is linked to the presence of specific oxidized polyunsaturated fatty acids in the HDL2 particles.
We observed an inverse relationship between several oxidized fatty acids, such as 18-hydroxyeicosapentaenoic acid (18-HEPE) and others, and platelet aggregation. This means that higher levels of these oxidized fats were associated with less platelet activation and clotting, pointing to their potential role in enhancing the antithrombotic properties of HDL2 in ACS patients.
Overall, the findings suggest that EPA and its oxidized metabolites could play a key role in modifying HDL properties, thereby offering some protection against blood clots in individuals with ACS.
It became clear that HDL2 from ACS patients exhibited a stronger ability to inhibit platelet aggregation compared to HDL from healthy individuals. This ability to reduce clot formation is linked to the presence of specific oxidized polyunsaturated fatty acids in the HDL2 particles.
We observed an inverse relationship between several oxidized fatty acids, such as 18-hydroxyeicosapentaenoic acid (18-HEPE) and others, and platelet aggregation. This means that higher levels of these oxidized fats were associated with less platelet activation and clotting, pointing to their potential role in enhancing the antithrombotic properties of HDL2 in ACS patients.
Overall, the findings suggest that EPA and its oxidized metabolites could play a key role in modifying HDL properties, thereby offering some protection against blood clots in individuals with ACS.
Read More
9
Fish oil may reduce clotting risk
We explored the effects of eicosapentaenoic acid (EPA) found in fish oil supplements on the risk of blood clotting in patients with suspected coronary artery disease who weren’t taking lipid-lowering medications. The study included 600 consecutive patients, and we compared those taking fish oil to those who weren’t.
Our findings showed that fish oil supplementation was associated with beneficial changes in several cholesterol levels, particularly lower levels of very low-density lipoprotein (VLDL) and intermediate-density lipoprotein (IDL) cholesterol. This aligns with evidence that EPA could play a role in heart health.
Notably, patients who took fish oil demonstrated reduced platelet aggregation and lower levels of urinary thromboxane B2, a marker associated with blood clot formation. This suggests that fish oil could potentially help in lowering atherothrombotic risk, especially for those not on other cholesterol-lowering treatments.
While the results are promising, further studies are warranted to confirm these findings and better understand the independent effects of EPA on blood clotting.
Our findings showed that fish oil supplementation was associated with beneficial changes in several cholesterol levels, particularly lower levels of very low-density lipoprotein (VLDL) and intermediate-density lipoprotein (IDL) cholesterol. This aligns with evidence that EPA could play a role in heart health.
Notably, patients who took fish oil demonstrated reduced platelet aggregation and lower levels of urinary thromboxane B2, a marker associated with blood clot formation. This suggests that fish oil could potentially help in lowering atherothrombotic risk, especially for those not on other cholesterol-lowering treatments.
While the results are promising, further studies are warranted to confirm these findings and better understand the independent effects of EPA on blood clotting.
Read More
8
We explored how omega-3 fatty acids, particularly eicosapentaenoic acid (EPA), influence blood clot markers in patients with atrial fibrillation (AF). Our research involved a large group of 2,373 patients, assessing the levels of D-dimer and beta-thromboglobulin (BTG), which are indicators of blood clotting activity and platelet activation.
The results showed that higher total omega-3 fatty acid levels were linked to lower D-dimer and BTG levels, which suggests a potential antithrombotic effect. Notably, the individual omega-3s, including EPA, docosahexaenoic acid (DHA), and others, generally displayed similar associations.
While EPA had a small positive relationship with BTG, DHA, DPA, and ALA were associated with lower BTG levels, indicating varied effects among these fatty acids. Overall, we found that increased omega-3 fatty acid levels could contribute to reduced activation of blood clotting mechanisms in patients with AF, highlighting the potential benefits of omega-3 intake for cardiovascular health.
The results showed that higher total omega-3 fatty acid levels were linked to lower D-dimer and BTG levels, which suggests a potential antithrombotic effect. Notably, the individual omega-3s, including EPA, docosahexaenoic acid (DHA), and others, generally displayed similar associations.
While EPA had a small positive relationship with BTG, DHA, DPA, and ALA were associated with lower BTG levels, indicating varied effects among these fatty acids. Overall, we found that increased omega-3 fatty acid levels could contribute to reduced activation of blood clotting mechanisms in patients with AF, highlighting the potential benefits of omega-3 intake for cardiovascular health.
Read More
8
We explored how fatty acids, specifically eicosapentaenoic acid (EPA), relate to the risk of blood clots known as venous thromboembolism (VTE). Through a Mendelian randomization study, we examined genetic variants linked to ten fatty acids sourced from large participant groups, including over 30,000 VTE cases.
Our findings revealed that for every standard deviation increase in genetically predicted levels of eicosapentaenoic acid, the odds of developing VTE increased by 16%. This indicates a potential risk factor associated with EPA rather than a beneficial effect.
Interestingly, while other fatty acids, like oleic and linoleic acids, were linked to a decrease in VTE risk, EPA did not show a protective benefit. It's essential to consider these varying effects when thinking about dietary modifications for blood clot prevention. In summary, while some fatty acids may help reduce the risk of blood clots, eicosapentaenoic acid appears to be associated with an increased risk instead.
Our findings revealed that for every standard deviation increase in genetically predicted levels of eicosapentaenoic acid, the odds of developing VTE increased by 16%. This indicates a potential risk factor associated with EPA rather than a beneficial effect.
Interestingly, while other fatty acids, like oleic and linoleic acids, were linked to a decrease in VTE risk, EPA did not show a protective benefit. It's essential to consider these varying effects when thinking about dietary modifications for blood clot prevention. In summary, while some fatty acids may help reduce the risk of blood clots, eicosapentaenoic acid appears to be associated with an increased risk instead.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 47 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Skin condition improved
25 people found this helpful
The ideal dosage for everyday vitamins comes in a plastic jar with protective mica on the lid. The sleek black design conveys quality. The capsules are large, dense, and rich golden colour, with no smell, which delighted me! They swallow easily with a glass of water, and I don’t feel them in my throat. No fishy burps or unpleasant aftertastes! I track my skin condition, especially dryness on my elbows and legs. Without omega, my skin stays dry, needing constant moisturising. With omega, my skin feels normal, soft, and delicate. I can't identify its effects on heart health or blood vessels, but I do maintain good blood pressure for my age.
Read More
9
Less eye fatigue
5 people found this helpful
These vitamins in a plastic jar with a mica lid caught my attention. I was struck by the sleek design, giving it a quality appearance. The large golden capsules are easy to swallow with water, and I've not experienced any unpleasant aftertaste or fishy burps after taking them. Since starting omega, the dry skin on my elbows and legs is no longer an issue; my skin feels soft and smooth. While I can't specifically judge its impact on my heart or joints, my blood pressure remains stable, which is normal for me. Additionally, I've noticed my eyes feel less tired during the day.
Read More
9
Improved skin quality
1 people found this helpful
The ideal dosage for daily vitamins comes in a plastic jar with protective mica on the lid, which I removed initially. The strict black design makes the dietary supplement look presentable and gives an impression of quality. The capsules are large, dense, and a rich golden colour, with no smell, which made me very happy! It swallows well with a glass of water without feeling stuck in my throat, and there's no fishy burp or aftertaste. My skin, which was dry and required moisturising creams without omega, has become soft and delicate with its reception. I haven’t noted its effect on the heart, blood vessels, or joints, except for maintaining good blood pressure appropriate for my age. My vision has improved, as my eyes feel less tired.
Read More
9
Vision fatigue reduced
1 people found this helpful
The ideal daily vitamin dosage is packaged in a plastic jar with protective mica on the lid, which I removed at the first inspection. The black design gives it a quality appearance. The large, dense capsules are rich golden colour and odourless, which pleased me! They swallow easily with water, and even though they're large, there's no feeling of obstruction in my throat. I haven’t experienced any fishy burps or unpleasant tastes! I monitor the results of taking it, particularly with my dry skin on the elbows and legs. Without omega, my skin is uncomfortably dry, but with omega, it’s soft and manageable. While I cannot comment on the impacts on my heart or blood vessels, I experience good, consistent blood pressure for my age, and I've noticed my eyesight feels less strained.
Read More
7
Stable blood pressure
1 people found this helpful
I appreciate the vitamins I found in a smart black jar with a mica lid. The capsules have a rich golden colour and are easy to swallow comfortably without objectionable flavours or aftertastes. The impact on my dry skin has been noteworthy, with omega making it smooth and soft instead of needing constant hydration. While I can't comment on the positives for my heart, blood vessels, and joints, aside from my reliably good blood pressure—normal for my age—I have certainly been delighted with a reduction in eye fatigue.
Read More
Frequently Asked Questions
9
Skin condition improved
25 people found this helpful
The ideal dosage for everyday vitamins comes in a plastic jar with protective mica on the lid. The sleek black design conveys quality. The capsules are large, dense, and rich golden colour, with no smell, which delighted me! They swallow easily with a glass of water, and I don’t feel them in my throat. No fishy burps or unpleasant aftertastes! I track my skin condition, especially dryness on my elbows and legs. Without omega, my skin stays dry, needing constant moisturising. With omega, my skin feels normal, soft, and delicate. I can't identify its effects on heart health or blood vessels, but I do maintain good blood pressure for my age.
7.5
No side effects noted
8 people found this helpful
The ideal dosage for everyday vitamins is packaged in a plastic jar with protective mica. I took it off initially, and the striking black design conveys sophistication and quality. The sizeable golden capsules are odourless and swallow easily with water, without discomfort or unpleasant aftertastes. I always monitor the effects on my skin. Without omega, it becomes very dry, but with it, my skin becomes soft and hydrated. While I haven't noticed effects on my heart or joints, I do have consistent blood pressure, which is normal for my age. My vision appears to have improved, resulting in less eye fatigue.
9
Less eye fatigue
5 people found this helpful
These vitamins in a plastic jar with a mica lid caught my attention. I was struck by the sleek design, giving it a quality appearance. The large golden capsules are easy to swallow with water, and I've not experienced any unpleasant aftertaste or fishy burps after taking them. Since starting omega, the dry skin on my elbows and legs is no longer an issue; my skin feels soft and smooth. While I can't specifically judge its impact on my heart or joints, my blood pressure remains stable, which is normal for me. Additionally, I've noticed my eyes feel less tired during the day.
8
We explored how omega-3 fatty acids, particularly eicosapentaenoic acid (EPA), influence blood clot markers in patients with atrial fibrillation (AF). Our research involved a large group of 2,373 patients, assessing the levels of D-dimer and beta-thromboglobulin (BTG), which are indicators of blood clotting activity and platelet activation.
The results showed that higher total omega-3 fatty acid levels were linked to lower D-dimer and BTG levels, which suggests a potential antithrombotic effect. Notably, the individual omega-3s, including EPA, docosahexaenoic acid (DHA), and others, generally displayed similar associations.
While EPA had a small positive relationship with BTG, DHA, DPA, and ALA were associated with lower BTG levels, indicating varied effects among these fatty acids. Overall, we found that increased omega-3 fatty acid levels could contribute to reduced activation of blood clotting mechanisms in patients with AF, highlighting the potential benefits of omega-3 intake for cardiovascular health.
The results showed that higher total omega-3 fatty acid levels were linked to lower D-dimer and BTG levels, which suggests a potential antithrombotic effect. Notably, the individual omega-3s, including EPA, docosahexaenoic acid (DHA), and others, generally displayed similar associations.
While EPA had a small positive relationship with BTG, DHA, DPA, and ALA were associated with lower BTG levels, indicating varied effects among these fatty acids. Overall, we found that increased omega-3 fatty acid levels could contribute to reduced activation of blood clotting mechanisms in patients with AF, highlighting the potential benefits of omega-3 intake for cardiovascular health.
8
We explored how fatty acids, specifically eicosapentaenoic acid (EPA), relate to the risk of blood clots known as venous thromboembolism (VTE). Through a Mendelian randomization study, we examined genetic variants linked to ten fatty acids sourced from large participant groups, including over 30,000 VTE cases.
Our findings revealed that for every standard deviation increase in genetically predicted levels of eicosapentaenoic acid, the odds of developing VTE increased by 16%. This indicates a potential risk factor associated with EPA rather than a beneficial effect.
Interestingly, while other fatty acids, like oleic and linoleic acids, were linked to a decrease in VTE risk, EPA did not show a protective benefit. It's essential to consider these varying effects when thinking about dietary modifications for blood clot prevention. In summary, while some fatty acids may help reduce the risk of blood clots, eicosapentaenoic acid appears to be associated with an increased risk instead.
Our findings revealed that for every standard deviation increase in genetically predicted levels of eicosapentaenoic acid, the odds of developing VTE increased by 16%. This indicates a potential risk factor associated with EPA rather than a beneficial effect.
Interestingly, while other fatty acids, like oleic and linoleic acids, were linked to a decrease in VTE risk, EPA did not show a protective benefit. It's essential to consider these varying effects when thinking about dietary modifications for blood clot prevention. In summary, while some fatty acids may help reduce the risk of blood clots, eicosapentaenoic acid appears to be associated with an increased risk instead.
8
We sought to understand how docosahexaenoic acid (DHA), an omega-3 fatty acid, influences blood clotting and platelet activity. To do this, we examined DHA and its oxidized forms, known as oxylipins (11-HDHA and 14-HDHA), to see how they affected platelet function and the formation of blood clots.
The results were promising. We found that DHA and its oxylipins reduced the clustering of human platelets triggered by collagen, a key factor in clot formation. Notably, the oxylipins were particularly effective; they not only limited platelet activation but also decreased the secretion of substances critical for clotting. When we tested these substances in whole blood, we noted a significant reduction in the ability of platelets to adhere to surfaces coated with collagen, which is crucial in the early stages of clot formation.
Interestingly, our findings indicated that while DHA showed some effects, the real benefits seemed to come from the oxylipins, especially 11-HDHA and 14-HDHA. In mice studies, thrombus formation was significantly reduced with these compounds, highlighting their important role in managing platelet activation. We also discovered that these effects were linked to the activation of protein kinase A, a pathway that plays a role in cell signaling.
Overall, our research offers valuable insights into how DHA and its oxidative products can help inhibit harmful clot formation. This could have important implications for utilizing DHA as a treatment strategy in cardiovascular health.
The results were promising. We found that DHA and its oxylipins reduced the clustering of human platelets triggered by collagen, a key factor in clot formation. Notably, the oxylipins were particularly effective; they not only limited platelet activation but also decreased the secretion of substances critical for clotting. When we tested these substances in whole blood, we noted a significant reduction in the ability of platelets to adhere to surfaces coated with collagen, which is crucial in the early stages of clot formation.
Interestingly, our findings indicated that while DHA showed some effects, the real benefits seemed to come from the oxylipins, especially 11-HDHA and 14-HDHA. In mice studies, thrombus formation was significantly reduced with these compounds, highlighting their important role in managing platelet activation. We also discovered that these effects were linked to the activation of protein kinase A, a pathway that plays a role in cell signaling.
Overall, our research offers valuable insights into how DHA and its oxidative products can help inhibit harmful clot formation. This could have important implications for utilizing DHA as a treatment strategy in cardiovascular health.
7
Eicosapentaenoic acid reduces thrombin generation
We aimed to understand how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, influences blood clotting and thrombus formation. To do this, we studied human platelets treated with EPA along with docosahexaenoic acid (DHA) and observed their responses when stimulated with various agonists related to thrombus development.
Interestingly, while we found minimal effects of n-3 PUFAs on basic platelet functions in the laboratory, EPA treatment significantly delayed thrombin generation, a key component in the clotting process. This effect was consistent in both human samples and mice on an n-3 PUFA-enriched diet.
We also discovered that the reduced thrombin production was accompanied by decreased platelet accumulation in developing thrombi in small arterioles and larger arteries. However, the treatment did not affect all aspects of platelet activation, such as the exposure of P-selectin.
Overall, while EPA didn't bring about dramatic changes in ex-vivo platelet functions, it did help lower thrombin generation, highlighting its potential role in reducing harmful blood clotting in the body.
Interestingly, while we found minimal effects of n-3 PUFAs on basic platelet functions in the laboratory, EPA treatment significantly delayed thrombin generation, a key component in the clotting process. This effect was consistent in both human samples and mice on an n-3 PUFA-enriched diet.
We also discovered that the reduced thrombin production was accompanied by decreased platelet accumulation in developing thrombi in small arterioles and larger arteries. However, the treatment did not affect all aspects of platelet activation, such as the exposure of P-selectin.
Overall, while EPA didn't bring about dramatic changes in ex-vivo platelet functions, it did help lower thrombin generation, highlighting its potential role in reducing harmful blood clotting in the body.
9
Eicosapentaenoic acid influences clotting
We explored how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, influences blood clotting processes. The interest in EPA grew substantially after the 1970s when researchers Dyerberg and Bang noted that Greenland Eskimos had lower rates of coronary disease linked to their diet rich in marine lipids.
Their findings suggested that the higher levels of EPA led to reduced platelet aggregation, which essentially means that the blood clots less easily. This anti-clotting effect is significant since blood clots can lead to serious health issues like heart attacks and strokes.
Although studies have shown these promising effects, it’s crucial to note that much of the initial acclaim came from dietary observations rather than controlled clinical trials. This means that while we can relate high EPA intake to lower health risks in specific populations, we still need more rigorous studies to fully understand the impact of EPA on blood clotting across diverse groups.
Their findings suggested that the higher levels of EPA led to reduced platelet aggregation, which essentially means that the blood clots less easily. This anti-clotting effect is significant since blood clots can lead to serious health issues like heart attacks and strokes.
Although studies have shown these promising effects, it’s crucial to note that much of the initial acclaim came from dietary observations rather than controlled clinical trials. This means that while we can relate high EPA intake to lower health risks in specific populations, we still need more rigorous studies to fully understand the impact of EPA on blood clotting across diverse groups.
8
We explored the role of eicosapentaenoic acid, provided through Lovaza, in enhancing the resolution of inflammation and promoting blood clot remodeling in patients with coronary artery disease (CAD). In a clinical trial involving six stable CAD patients, half were treated with daily doses of Lovaza for a year, while the others did not receive this supplement.
Our analysis revealed an intriguing finding: patients not taking Lovaza had significantly lower levels of specialized proresolving lipid mediators (SPMs), which play a crucial role in clearing inflammation and aiding clot remodeling. However, those on Lovaza showed restored levels of key SPMs, such as AT-RvD3 and AT-LXB4, effectively improving the environment for macrophages – the cells responsible for engulfing and digesting blood clots.
While Lovaza treatment led to an increase in beneficial SPMs by about 50%, the absence of certain resolvins in CAD patients suggests a link to chronic vascular inflammation and thrombosis. Overall, these insights shine a light on how eicosapentaenoic acid could potentially support better clot management, though we note that further research may be needed to clarify these benefits in broader contexts.
Our analysis revealed an intriguing finding: patients not taking Lovaza had significantly lower levels of specialized proresolving lipid mediators (SPMs), which play a crucial role in clearing inflammation and aiding clot remodeling. However, those on Lovaza showed restored levels of key SPMs, such as AT-RvD3 and AT-LXB4, effectively improving the environment for macrophages – the cells responsible for engulfing and digesting blood clots.
While Lovaza treatment led to an increase in beneficial SPMs by about 50%, the absence of certain resolvins in CAD patients suggests a link to chronic vascular inflammation and thrombosis. Overall, these insights shine a light on how eicosapentaenoic acid could potentially support better clot management, though we note that further research may be needed to clarify these benefits in broader contexts.
References
- Reiner MF, Bertschi DA, Werlen L, Wiencierz A, Aeschbacher S, et al. Omega-3 Fatty Acids and Markers of Thrombosis in Patients with Atrial Fibrillation. Nutrients. 2024;16. doi:10.3390/nu16020178
- Lu LW, Quek SY, Lu SP, Chen JH. Potential Benefits of Omega-3 Polyunsaturated Fatty Acids (N3PUFAs) on Cardiovascular Health Associated with COVID-19: An Update for 2023. Metabolites. 2023;13. doi:10.3390/metabo13050630
- Yuan S, Li X, Morange PE, Bruzelius M, Larsson SC. Plasma Phospholipid Fatty Acids and Risk of Venous Thromboembolism: Mendelian Randomization Investigation. Nutrients. 2022;14. doi:10.3390/nu14163354
- Nakao S, Ishihara T, Tsujimura T, Iida O, Hata Y, et al. Effectiveness of hospital lipid-lowering protocol of intensive lipid-lowering therapy for patients with acute coronary syndrome. J Cardiol. 2022;79:391. doi:10.1016/j.jjcc.2021.10.005
- Djuricic I, Calder PC. Beneficial Outcomes of Omega-6 and Omega-3 Polyunsaturated Fatty Acids on Human Health: An Update for 2021. Nutrients. 2021;13. doi:10.3390/nu13072421
- Gaertner S, Auger C, Farooq MA, Pollet B, Khemais-Benkhiat S, et al. Oral Intake of EPA:DHA 6:1 by Middle-Aged Rats for One Week Improves Age-Related Endothelial Dysfunction in Both the Femoral Artery and Vein: Role of Cyclooxygenases. Int J Mol Sci. 2020;21. doi:10.3390/ijms21030920
- Akintoye E, Sethi P, Harris WS, Thompson PA, Marchioli R, et al. Fish Oil and Perioperative Bleeding. Circ Cardiovasc Qual Outcomes. 2018;11:e004584. doi:10.1161/CIRCOUTCOMES.118.004584
- Spector AA, Kim HY. Emergence of omega-3 fatty acids in biomedical research. Prostaglandins Leukot Essent Fatty Acids. 2019;140:47. doi:10.1016/j.plefa.2018.11.017
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